Innovation In AI with the Mayo Clinic

Discover how Mayo Clinic is pioneering the future of healthcare. Go beyond the technology to see how AI is amplifying their historic, compassion-driven mission, freeing caregivers to focus on what truly matters: the patient. Emily Godsey, Administrator of Innovation & Digital Transformation for the Mayo Clinic, and Scott Helgeson, Doctor of Medicine and Assistant Professor at the Mayo Clinic, reveal a powerful vision for a more human-centered and proactive model of medicine.

The Health AI Forum is sponsored by the Lucy Family Institute for Data & Society. Please visit the Health AI Forum website for more information.

Introduction: Setting the Stage for Medical Innovation
The integration of artificial intelligence into healthcare is not just a technological challenge; it is a strategic and ethical imperative that promises to reshape patient care. In a recent session, Emily Godsey, an administrator at Mayo Clinic in Florida with an assignment in digital transformation, and Dr. Scott Helgeson, a pulmonologist and physician lead for Ambient Clinical Intelligence, offered a compelling look inside Mayo Clinic’s approach. They detailed how one of the world’s leading medical institutions is pioneering AI not to replace its caregivers, but to amplify what they call the “Mayo magic”—a profound human connection that, as one physician described, allows patients to feel “joy” even in their darkest moments. Mayo Clinic’s journey serves as a powerful case study in balancing cutting-edge technological advancement with the timeless art of compassionate care.
The Foundation: A Mission Born from History
To understand Mayo Clinic’s digital future, one must first look to its past. The institution’s innovation strategy is anchored in a defiant spirit born from disaster. After a devastating tornado wiped out Rochester, Minnesota in 1883, a local Franciscan sister, Sister Alfred Mo, approached Dr. W.W. Mayo with a vision to build a world-renowned hospital “within the cornfields.” Dr. Mayo initially thought she was “a little crazy,” but Sister Mo was undeterred, telling him, “no listen we’re going to do it and we’re just going to drag you there if we have to.” It was this determined partnership that established the hospital and instilled its guiding values. That foundational vision—that any patient could receive care, regardless of who they were—translates directly into their primary value today: the needs of the patient come first. This unwavering commitment is not just a historical footnote; it is the direct impetus for Mayo’s radical digital strategy, born from the urgent realization that their old models of care cannot meet future demand.
The Strategy: Making the Campus a Member of the Care Team
Recognizing that mounting patient demand, space constraints, and staffing shortages made their current model unsustainable, Mayo Clinic made a series of “big bets” that necessitated a radical transformation of their care delivery philosophy. Their solution is to make the campus an active member of the care team. This vision is operationalized through a simple yet powerful “Sense, Think, Act” framework designed to create an intelligent, responsive care environment.
• Sense: The campus is being outfitted with an array of ambient sensors and cameras to continuously and unobtrusively collect data about the patient environment.
• Think: This vast stream of data is fed into sophisticated AI models. For example, by analyzing video and audio, an algorithm can identify the early warning signs of delirium. Where a nurse might perform a check “every 3 hours or so,” the AI system provides an assessment “every second,” offering continuous vigilance.
• Act: When the system detects a potential issue, it automatically alerts the right clinician at the right time. This enables caregivers to intervene proactively, transforming care from a reactive process to a predictive one.
For Godsey, the goal of this framework is deeply personal. She recounted accidentally wandering into a “blessing of the hands” ceremony for new nurses, a tradition dating back to Mayo’s founding. The experience crystallized her motivation: “I don’t want to bless a hand to type on a keyboard,” she explained. The system’s purpose is to liberate clinicians from screens, allowing their blessed hands to touch people and their eyes to look at people—preserving the human-to-human moments that define great care.
Innovation in Practice: From Theory to the Bedside
Dr. Helgeson provided tangible examples of how this “Sense, Think, Act” model is being applied at the bedside. These projects are not simple implementations; they are the result of overcoming immense strategic challenges, particularly in data access. As Dr. Helgeson noted, renegotiating vendor contracts to reclaim decades of proprietary patient data can take “years,” a critical and arduous step before innovation can even begin.
• Objective Pain Assessment Computer vision models are being trained to analyze facial expressions—such as brow lowering and nose wrinkling—to create an objective, continuous measurement of pain. The research fellow cleverly named the model “YOLO” for “You Only Look Once.” This technology moves beyond the limitations of the subjective 1-to-10 pain scale, allowing for more proactive and precise pain management, especially for patients who cannot self-report.
• Predicting Transplant Rejection For lung transplant recipients, chronic rejection is a constant risk. By applying AI to analyze years of longitudinal data from pulmonary function tests, Mayo Clinic can now predict the likelihood of transplant failure weeks or even months in advance. This early warning gives clinicians a critical window to intervene with treatments that can save both the organ and the patient’s life.
These projects exemplify a fundamental shift toward a more predictive, personalized, and deeply humane standard of care.
Conclusion: The Future of Compassionate Technology
The core message from Mayo Clinic is clear: artificial intelligence is not an end in itself, but a powerful tool to preserve and enhance the “Mayo magic.” By strategically deploying technology to handle the burdens of data monitoring and documentation, Mayo aims to build a protective “moat” around its most valuable asset: its people. The future they are building is one where technology works silently in the background to make healthcare more efficient, more predictive, and, most importantly, more human, ensuring that patients continue to find joy and connection when they need it most.

• Values-Driven Innovation Mayo Clinic’s adoption of AI is not driven by technology trends but is firmly rooted in its 140-year-old mission. The foundational value—”the needs of the patient come first”—acts as a strict filter, ensuring that every technological initiative is purposefully designed to enhance patient care and the human experience.
• The Campus as a Proactive Care Partner The “Sense, Think, Act” model represents a paradigm shift in how a hospital functions. By transforming the physical environment into an intelligent system that monitors patients and alerts staff, Mayo is creating a setting that actively participates in care, helping to prevent crises before they occur.
• Augmenting, Not Replacing, the Human Touch A core philosophy is that AI’s primary purpose is to augment, not replace, human caregivers. By automating tasks like data collection and analysis, the technology aims to free clinicians from administrative burdens, allowing them to dedicate more time and focus to direct, compassionate patient interaction.
• Shifting from a Reactive to a Predictive Model of Care Practical applications, like using computer vision for objective pain assessment and AI models to predict organ rejection, demonstrate a fundamental change in clinical practice. This approach allows clinicians to anticipate adverse events and intervene early, which can dramatically improve outcomes and save lives.
• Data as a Foundational (and Challenging) Asset The presenters underscored that high-quality, longitudinal patient data is the essential fuel for these AI innovations. However, gaining access to this data, especially from third-party medical device vendors, is a major strategic hurdle that requires years of effort in renegotiating contracts and building new data infrastructure.

• “what to me is i see at mayo that’s different… is that even in the darkest times when things are unknown our patients still feel joy.” – Anonymous Physician, quoted by Emily Godsey
• “I don’t want to bless a hand to type on a keyboard though it is still important but let’s bless the hands so that they can touch people and so their eyes can be looking at people.” – Emily Godsey
• “our solution was for now what we’re charging toward is make our campus a member of our care team.” – Emily Godsey
• “from the clinical side the most important thing from me is… anything that can help me do my job more efficiently be… proactive and not reactive that is very key when minutes can be someone’s life in the hospital.” – Dr. Scott Helgeson
• “…these will never replace the physical hands on a patient which [it] goes back to laying on the hands.” – Dr. Scott Helgeson

Health and SocietyScience and TechnologyArtificial IntelligenceHealthcareLucy Family Institute for Data & SocietyUniversity of Notre Dame

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