Developing an ‘on and off’ Switch for Breast Cancer Treatment

T-cells play an important role in the body’s immune system, and one of their tasks is to find and destroy infection. However, T-cells struggle to identify solid, cancerous tumors in the body. A current cancer therapy is using these T-cells and genetically engineering them to kill cancer, but these cells, known as CAR-T cells, have been known to attack off-target sites while completing their job. In order to counteract this negative effect, University of Notre Dame researchers are working to create nanoparticles that act as an “on and off” switch to improve the safety and effectiveness of this cancer therapy.

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